BMM202

School of Engineering \ Biomedical Engineering

3

6

Compulsory

Turkish

-

Department of Biomedical Engineering Department

This course covers key discoveries in the history of cell and molecular biology along with the following topics: protein transport to membranes and organelles; protein modification, folding, and quality control in the ER; vesicular trafficking, secretion, and endocytosis; protein transport to mitochondria, chloroplasts, peroxisomes, and the nucleus; cell imaging (microscopy); purification of cellular organelles; protein purification and analysis, proteomics; structural organization of eukaryotic chromosomes and chromosomal mutations; eukaryotic gene structure, chromosomal organization of genes, non-coding DNA, transposable DNA elements, organelle DNA, molecular genetic techniques, gene mutations; cell culture, cell birth, and lineage maintenance; stem cells and stem cell technology; cellular aging, cell death, and the regulation of cell death; and cancer.

• Moleküler Hücre Biyolojisi –Lodish . 6. baskıdan çeviri, Palme Yayıncılık
• Genetik Kavramlar- William S. Klug, Michael R. Cummings, Charlotte A. Spencer- 8. baskıdan çeviri, Palme Yayıncılık, 2011

The aim of BMM 202 course is to provide students with up-to-date knowledge at a foundational level on topics essential for Biomedical Engineering education, such as molecular biology, cell biology, genetics, physiology, tissue engineering, pharmacology and toxicology, biotechnology, genetic engineering, nanomedicine, biosensors, bioinformatics, drug design, and enzymology. Additionally, it aims to offer insights into how they can apply this knowledge in their professional careers.

1. Gaining up-to-date knowledge that forms a foundation for more specific fields such as molecular biology, cell biology, physiology, tissue engineering, pharmacology, toxicology, biotechnology, genetic engineering, nanomedicine, biosensors, bioinformatics, drug design, and enzymology.
2. Acquiring insights into where this knowledge can be applied in professional life.
3. Gaining experience in accessing information, conducting literature searches, and citing references in the field of molecular biology and biotechnology.

1. Week Introduction to the course, important steps in the history of molecular biology
2. Week Transport of proteins to membranes and organelles
3. Week Vesicular traffic, secretion and endocytosis
4. Week Imaging of cells (microscope), purification of cell organelles
5. Week Purification and study of proteins, Proteomics
6. Week Structural organization of eukaryotic chromosomes and chromosomal mutations
7. Week Eukaryotic gene structure, chromosomal organization of genes and non-coding DNA, transposable DNA elements, organelle DNA
8. Week Gene mutations
9. Week Cell culture, birth of the cell, continuation of the cell line
10. Week Stem cell and stem cell technology
11. Week Cellular aging, cell death and regulation of cell death
12. Week Cancer