School of Engineering \ Biomedical Engineering
Course Credit
ECTS Credit
Course Type
Instructional Language
Programs that can take the course
BMM 427 introduces general concepts in synthetic biology which emerged as a promising field combining and utilizing recent developments in molecular biology, genetics, chemistry and genome engineering
Textbook and / or References
• Science
• Nature
• ACS Synthetic Biology
• PNAS
• Nature Communications
• Cell
• Nature Reviews Bioengineering
• Nature Reviews Drug Discovery
BMM 422 aims to introduce general concepts in synthetic biology to senior Biomedical Engineering undergraduates such as providing enhanced functions for living organisms with metabolic pathway rearrangement at the genetic level, using live cells for bioproduction, developing therapeutics for genetic and metabolic diseases, and cell-free gene expression
1. Being able to comprehend the scope of synthetic biology, its applications, its differences from previous technologies, and its potential contributions to various fields such as medicine, agriculture, environment, production and alike.
2. Understanding the mechanims behind synthetic biology methods such as mRNA vaccines, CRISPR, PROTAC, directed evolution, genome recoding, living therapeutics, cell-free gene expression
Week 1 What is synthetic biology?
Week 2 CRISPR genome editing
Week 3 mRNA vaccines
Week 4 Genome recoding
Week 5 Cell-free gene expression
Week 6 Living therapeutics
Week 7 Continuous directed evolution
Week 8 PROTACs
Week 9 CAR-T cells
Week 10 Base editing
Week 11 Prime editing
Week 12 Epigenome editing & the future of synthetic biology
Tentative Assesment Methods
• Mid-term % 45
• Final % 55
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