BMM442

School of Engineering \ Biomedical Engineering

3

6

Elective

English

KİM 101

Department of Biomedical Engineering

This course provides a comprehensive introduction to natural and synthetic polymer-based biomaterials used in the field of biomedical engineering. Students will learn about the properties of polymers and the characteristics that polymer-based biomaterials must possess (such as biocompatibility), as well as the production techniques and characterization methods for these materials. It will examine the applications of these materials in wound healing, controlled drug delivery, and soft and hard tissue engineering. In addition, software used in the computational design of polymer biomaterials will be discussed, and recent work on the clinical application of 3D printing techniques will be addressed. Regulations regarding the evaluation of polymer-based biomaterials will also be addressed. The course aims to develop the ability to evaluate the design and clinical applications of polymer-based biomaterials through theoretical lectures, case studies, and student presentations.

• Polymeric Biomaterials: Structure and Function, Severian Dumitriu, CRC Press, 2013
• Polymers as Biomaterials, Shalaby W.,Springer, 1984
• Up-to-date papers

1. To understand the chemical structure, properties, and morphology of polymer-based biomaterials.
2. To provide basic knowledge and understanding of the use of natural and synthetic polymers in biomedical applications.
3. To teach methods for categorizing biomaterials.
4. To enable students to select the necessary biomaterial and understand the differences between various biomaterials.
5. To teach methods used to repair damaged or lost tissue with polymer-based biomaterials.
6. To provide theoretical and practical knowledge about biocompatibility, production techniques, and characterization methods.
7. Teach the applications of polymer-based biomaterials in wound healing, drug delivery, and soft and hard tissue engineering.
8. Understand the role of advanced technologies such as computational design and 3D printing in biomaterial development.
9. Understand the impact of regulations and international standards on polymer-based biomaterial design and clinical use.
10. Develop students' skills in literature research, design proposal development, report preparation, and presentation.

1. Using the fundamentals of physics, chemistry, biology, and physiology, select the appropriate polymer-based biomaterial for a specific biomedical application and discuss the differences between various biomaterials at a basic level.
2. Using engineering knowledge to analyze, explain, and provide examples of the applications of natural and synthetic polymers in biomedical engineering (wound healing, drug delivery, soft and hard tissue engineering, etc.).
3. Evaluate the use of polymer-based biomaterials for the repair of damaged or lost tissue that can be used in living systems.
4. Explain biocompatibility, production techniques, and characterization methods in the context of interactions between living and non-living materials and biological systems.
5. Explain the principles of using 3D printing technologies in the biomaterial development process and select the appropriate method.
6. Interpreting the effects of medical device regulatory requirements and international standards on the development of biomaterials and their clinical applications in living systems.
7. Searching the scientific literature in the field of biomaterials, analyzing the data obtained, preparing technical reports, developing design proposals, and presenting their work in written and oral form.

Week 1: Introduction to Polymer-Based Biomaterials
Week 2: Classification of Polymers
Week 3: Properties of Polymers
Week 4: Production Techniques for Biomedical Polymers
5. Week: Characterization of Polymer-Based Biomaterials
Week 6: Biomaterials for Wound Healing and Drug Delivery
Week 7: Applications of Polymer-Based Biomaterials: Soft Tissue Engineering
Week 8: Applications of Polymer-Based Biomaterials: Hard Tissue Engineering
Week 9: Computational Design of Polymer Biomaterials
Week 10: 3D Printing of Tissue Scaffold Structures
Week 11: Biomaterials Requirements: Evaluation Standards and Regulations for Polymer-Based Biomaterials
Week 12: Biomaterials Evaluation Standards and Student Presentations