BMM443

School of Engineering \ Biomedical Engineering

3

6

Elective

English

-

Department of Biomedical Engineering

Drug discovery, pharmacokinetics, traditional drug delivery problems and solutions to these challenges in nanomedicine applications, classification of nanomedicine platforms, guidance strategies in nanomedicine, therapeutic, diagnostic and theranotherapeutic nanomedicine applications, production techniques of popular particle types, problems and new approaches in the field of nanomedicine are presented to the students.

Up-to-date articles

Within the scope of this course, an overview of drug development is provided, pharmacokinetic concepts and information about the current pharmaceutical industry are presented, and the market launch stages of drugs are examined. Subsequently, the problems in drug delivery and the solutions offered by nanotechnology, targeting, smart delivery systems and theranostic approaches are explained and organic, inorganic and composite carrier types and applications with differentiated surfaces are introduced to the students.

1. Stages of drug discovery, derivations of formulas in pharmacokinetics, learning current problems in drug transport, understanding physiological changes in disease processes, accumulation points of nanoparticles in the body and barriers to overcome
2. To learn the particle types and targeting pathways used in nanomedicine, to understand the advantages of nanoparticles compared to classical therapy and drug loading strategies in polymeric and micellar nanoparticles
3. To learn the production stages of silica, metal and superparamagnetic nanoparticles and their physicochemical properties that enable their use in diagnosis and treatment and to gain an idea about their usage areas
4. Students are expected to present a current nanomedicine application with a particle type that is not covered in this course.

Week 1: Traditional Drug Discovery, Transport, Pharmacokinetics and Problems
Week 2: Principles of Nanomedicine
Week 3: Principles of Nanomedicine, Targeting and Barriers
Week 4: Nanomaterial Classifications and Micelles
Week 5: Micelles and Polymeric Nanomaterials Production and Applications
Week 6: Nanomedicine via Polymeric Nanoparticles
Week 7: Silica Based Nanoparticle Preparation and Properties
Week 8: Nanomedicine via Silica Based Nanoparticles
Week 9: Metallic Nanoparticle Preparation and Properties
Week 10: Nanomedicine via Metallic Nanoparticles
Week 11: Preparation and Properties of Superparamagnetic Nanoparticles
Week 12: Nanomedicine via Superparamagnetic Nanoparticles