TIP103

School of Medicine \ Medicine

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9

Compulsory

Turkish

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Bachelor's and Master’s

In Medical Biochemistry courses, metabolic pathways related to the breakdown of fats and proteins, electron transport system, modified biosynthetic metabolic pathways and biochemistry of some organelles are explained. In the Medical Biology department, DNA technology and methods preparation methods, non-Mendelian inheritance, cell theory and cancer biology can be discussed. Histological features of organelles in the cell structure and histological techniques are given. Project studies carried out within the scope of good practices in medicine courses, medical waste management, decontamination of the materials contained, pulse and blood pressure measurements, presentation methods are given. Basic homeostatic mechanisms, functional properties of the cell membrane, potential potentials and substance transport are discussed.

"Lehninger Principles of Biochemistry, 8th Edition, D. L. Nelson, M. M. Cox. WH Freeman
and Company 2021.
Molecular Biology of the Cell, 6th Edition, B. Alberts, A. Johnson, J. Lewis, D. Morgan,
M. Raff, K. Roberts, P. Walter. Garland Science, Taylor & Francis 2015.
Berne & Levy Physiology, 6th Updated Edition, with Student Consult Online Access,
Koeppen BM, Stanton BA, 2009.
Vander's Human Physiology: The Mechanisms of Body Function. , 15th Ed. Eric W,
Hershel R. 2019.
Sağlık Bilimlerinde Bilimsel Araştırma Yöntemlerine Giriş. Burak Mete, Hakan
Demirhindi. Akademisyen Kitabevi, 2022. "

The purpose of this course is to teach the basic metabolic information and biophysical principles of medical education.

1. Glycolysis, TCA subject, oxidation of fatty acids and metabolism of amino acids show the steps, parts and control mechanisms of the pathways.
2. Distributes why ammonia is toxic and describes how the product works
3. How RNA therapy and genetic information accumulation emerged
4. Folds the processes of transcription and protein synthesis (translation) into steps
5. Acquires basic biophysical information (units and measurements, cellular models).
6. Describes the functional properties of the cell membrane and the processes of transport of molecules through the membrane
7. Mobile adaptability in neurons and muscles, open action potential
8. Basic tests used in statistical evaluations (single ratio test, parametric) and nonparametric independent two-group comparison)
9. Use of formulas in physiological signals, how nomograms and graphs are assessment requirements
10. Stored depending on osmotic pressure, using elodea plant and blood records recognized under a microscope
11. Also in a laboratory environment Shows how the electron transport system works via the reduction of methylene blue.

Week 1: THEORETICAL glycolysis and its control - Flow of genetic information and RNA structure - Biophysical units and measurements - What is a hypothesis? Hypothesis testing - Article reading - Diffusion and osmosis in biological systems - Transcription and mRNA processing - Tricarboxylic acid cycle - Fatty acid oxidation - Ionic currents and membrane potential
Week 2: Nobel Prize 1953: Hans Adolf Krebs and Fritz Albert Lipmann, Citric acid cycle, Coenzyme A and its importance in intermediary metabolism - Introduction to Physiological Sciences - Measuring body temperature, respiratory rate, pulse, and arterial blood pressure - Common Courses
Week 3: THEORETICAL non-coding RNAs - Oxidation of amino acids and detoxification of ammonia - Measuring body temperature, respiratory rate, pulse, and arterial blood pressure - Practice - Genetic code - P value, Type I and Type II errors, study power - Basic physiological mechanisms and homeostasis
Week 4: Membrane potential of excitable cells - Measuring body temperature, respiratory rate, pulse, and arterial blood pressure - Evaluation - Protein synthesis - Physiological signals and their evaluation - Basic electrical principles - Electrical model of the cell membrane - Opening a syringe
Week 5: Drawing medication from an ampoule into a syringe, intramuscular injection - Biochemistry Lab: Transamination and paper chromatography - Common Courses, Theoretical genome anatomy
Week 6: Electron transport system and oxidative phosphorylation - Pentose phosphate and glucuronic acid metabolic pathways - Mutation and mutagenesis - One-sample t-test - Functional properties of the cell membrane and transport across the membrane - Types of mutation - Cable theory and conduction in axons - Gluconeogenesis - Gluconeogenesis
Week 7: THEORETICAL glycogen degradation and synthesis - Physiology Lab: Introduction to the physiology laboratory - Biophysics Lab: Factors affecting the electrical potential of the cell membrane - Biochemistry Lab: Electron transport chain - Physiology Lab: Use of formulas in physiological signals, evaluation of nomograms and graphs - Common Courses
Week 8: Genetic control mechanisms – Prokaryotes - Opening a syringe, drawing medication from an ampoule, intramuscular injection - Practice - Fatty acid synthesis - Comparison of two independent groups – Parametric - Lipid synthesis - Electrical potentials of the membrane in the neuron model
Week 9: Electrical excitability and action potential in the neuron model - Physiology Lab: Osmotic pressure: Elodea experiments - Biophysics Lab: Action potential and nerve conduction velocity - Common Courses, Theoretical synthesis of amino acids and other nitrogenous compounds
Week 10: Mendelian principles - Fundamentals of bioelectric measurement - Mendelian genetics in medicine - Biophysics: Discussion - Biophysics: Discussion - Comparison of two independent groups – Non-parametric - Opening a syringe, drawing medication from an ampoule, intramuscular injection - Evaluation
Week 11: Models of inheritance - Nucleotide synthesis - Non-Mendelian inheritance - Biochemistry: Discussion - Other electrically excitable cells – Muscle - Receptor cells - Article reading - Physiology Lab: Osmotic pressure: Blood experiments - Common Courses
Week 12: THEORETICAL Physiology Lab: Make-up - Biochemistry Lab: Make-up - Biophysics Lab: Make-up - TIP103 End-of-Block Theoretical Exam - TIP103 End-of-Block Practical Exam - Biophysics - TIP103 End-of-Block Practical Exam - Physiology - Common Courses

• Theoretical exam: 67 %
• Laboratory: 30 %
• Practical: 3 %