TIP301

School of Medicine \ Medicine

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10

Compulsory

Turkish

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Bachelor's and Master's Degrees

This course includes pathology, medical microbiology and parasitology, medical pharmacology courses and related clinic courses. During the course, pathophysiological processes of neoplastic, hematological and dermatological diseases, their clinical presentations and basic pharmacological information related to these diseases, as well as an introduction to laboratory practices, basic epidemiological concepts and techniques and health organization in Türkiye are examined.

Akılcı Tedavi Yönünden Tıbbi Farmakoloji 1-2, S. O. Kayaalp, Pelikan Tıp K. , 2024. Basic and Clinical Pharmacology, 16th Edition, B. Katzung and A. Trevor, Lange-
McGraw-Hill Medical, 2023
Rubin's Pathology: Clinicopathologic Foundations of Medicine, 7th Ediition,
D. S. Strayer, Wolters Kluwer, 2014
Robbins Temel Patoloji, Çev. Ed. S. Tuzlalı, Nobel Tıp Kitabevi, 2014
Cellular and Molecular Immunology, 8th Edition, AK Abbas, Saunders, 2014
Tıbbi Mikrobiyoloji, Çeviri Ed. Prof. Dr. Osman Şadi Yenen, Nobel Tıp K. , 2014

The purpose of this course is to provide students who have grasped the normal functioning of the human body and the basic mechanisms of diseases with the opportunity to understand the complaints and clinical signs and symptoms caused by neoplasia, blood and skin diseases and to learn the pharmacological agents used in treatments. In addition, it aims to provide information about the organization of the health structure and use basic epidemiological concepts and gain basic medical skills

1. Explains the concepts of neoplasia and malignancy, and distinguishes between malignant and benign.
2. Describe the importance of the laboratory in diagnosis and treatment follow-up and quality control.
3. Describes how to evaluate peripheral smear, and outlines normal and abnormal appearances in peripheral smear.
4. Defines acute inflammation, and lists laboratory markers used in diagnosis and follow-up.
5. Describes the classifications used in the diagnosis of hematological system diseases and the mechanisms of disease formation, and outlines their clinical presentations.
6. Defines neoplasia, and lists tumor markers used in diagnosis and follow-up.
7. Describes the mechanisms of formation of major hematological and lymphoid malignant diseases, and outlines their clinical presentations.
8. Describes the classifications used in the diagnosis of dermatological system diseases and the mechanisms of disease formation.
9. Describes the clinical presentations of dermatological system diseases.
10. Can define how health service delivery is organized in Türkiye
11. Can define epidemiological studies, can perform basic epidemiological calculations on data.
12. Can monitor health risks, health protection, environmental health, and chronic diseases in the community it covers (continuous target throughout the year)

Week 1: Introduction to the third-year course program, Neoplasia nomenclature and general characteristics, Radiological imaging, Biological effects of radiation, Introduction to Clinical Biochemistry: The role of the laboratory in diagnosis, correct sample collection and storage, sources of error, quality control, burns, Epidemiology, precancerous lesions, molecular pathology, Reactive radicals and their effects in biological systems, Antioxidant defense systems in biological systems, Infectious diseases from past to present COMMON COURSES Cancer biochemistry, carcinogenesis, Drugs used in the treatment of anemia, ESR, CRP and other inflammation mediators: Evaluation from the perspective of clinical biochemistry, Acute inflammation, its markers and biochemistry of tissue injury, Paraneoplasia, tumor immunity and diagnostic approaches, Pharmacology of the hematopoietic system, Elementary lesions of the skin and skin examination, Pruritus and its causes, Bone marrow structure and function, hematopoiesis, Hematopoietic stem cell.
Week 2: Childhood tumors, LAB: Tumor pathology, Drugs used in allergic reactions-1 (antihistamines, steroids, etc. ), Clinical biochemistry of body fluids, Psoriasis, Oral ulcer-genital ulcer, Drugs for ectoparasitic diseases of the skin and appendages, Infections causing hepatosplenomegaly and lymphadenopathy, Infections causing hepatosplenomegaly and lymphadenopathy, Elementary lesions of the skin, Pigmented lesions COMMON COURSES Skin findings of systemic diseases, Clinical findings in skin tumors, Inheritance of diseases and mechanisms of inheritance, Genetic material changes and diseases, inflammatory dermatoses, vesiculobullous diseases, erythrocyte metabolism disorders 1: Hemoglobinemias, erythrocyte metabolism disorders 2: Enzyme deficiencies and spherocytosis, the role of parasites in diseases and diagnostic methods, epithelial and dermal tumors, Lab: skin disease pathology
Week 3: Lymph node diseases, spleen and thymus diseases, blood and tissue parasites, vitiligo - alopecia areata, herpes simplex and varicella zoster skin infections, Genetic material changes and diseases, iron metabolism, iron deficiency anemia, blood and tissue parasites, non-Hodgkin lymphomas, drug and other agent-related skin rashes, erythema nodosum - erythema multiforme, COMMON COURSES Tumor markers, antimalarial drugs and antibiotics for blood and tissue protozoans, molecular and genetic basis of cancer, cancer genetics, Hodgkin lymphomas, plasma cell and myeloid neoplasms, chemotherapy principles, immune modulatory drugs, myeloid neoplasms, spleen and thymus diseases, approach to cancer patient, chronic disease anemia, hemolysis
Week 4: Chemotherapeutics (Cytotoxic agents: alkylating agents, antimetabolites, cytotoxic antibiotics, alkaloids, taxanes, camptothecins), Infections transmitted by blood and body fluids and protection methods, Organizational structure, duties and functions in health service provision in Türkiye, Acquired hemolytic anemia, Megaloblastic anemia, LAB: Lymphoid system pathologies Chemotherapeutics (hormones and drugs acting through hormones, protein kinase inhibitors, monoclonal antibodies, cytokines, other agents, Hemostasis, Thrombosis and fibrinolysis COMMON COURSES Acquired bleeding tendencies, Myeloproliferative diseases, Chronic Myelocytic Leukemia, Chronic Lymphocytic Leukemia, Malignant Lymphoma, Malignant Lymphoma FORMATIVE EXAM, COMMON COURSES
Week 5: LAB: Pathology Make-up, 301 COURSE BOARD EXAM, Evaluation of theoretical exam answers
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• Theoretical exam: 91 %
• Laboratory: 5 %
• Practical: 4 %