School of Medicine \ Medicine
	
	
	
 
				
	Course Credit
	ECTS Credit
	Course Type
	Instructional Language
 
				
	
					
					(TOBB ETÜ) Tıp Fakültesi Beşinci sınıfı başarıyla tamamlayarak sınıfı geçmeye hak kazanmış olmak.
				
	
	
	
 
				
	Programs that can take the course
	
	
	
 
	Medicine Bachelor's Degree Program
	
	
	
 
				
	To provide intern doctors with the skills to use the theoretical knowledge of medical pharmacology they have learned rationally in the clinic in front of the patient, to write prescriptions, to transfer the prescription to the patient, and to monitor the treatment. 
	
	
	
 
				
	Textbook and / or References
	
	
	
 
	Akılcı Tedavi Yönünden Tıbbi Farmakoloji 1-2, S. O. Kayaalp, Güneş Tıp K. , 2012
 Basic and Clinical Pharmacology, 13th Edition, McGraw-Hill Medical, 2014, 
Drug usage guides. 
	
	
	
 
				
	Identification of the disease in the target of the P-drug, determination of treatment targets, obtaining preliminary information on how to select personal drugs called P-drugs, defining the necessity of developing a P-drug list and the principles to be considered in the drug selection process. Defining the steps and principles of P-drug selection, explaining their use in practice. Explanation of P-Treatment selection and what to consider in practice. Treating patients with different complaints with P-drugs and evaluating the suitability of the P-drug for the patient, explaining this to the patient after deciding on the treatment plan, learning the principles of treatment monitoring, evaluating the effectiveness and side effects of the treatment, determining how to decide whether to continue, change or stop the treatment. 
	
	
	
 
				
	
					
						1. By learning the concept of K-drug, he/she can make a K-group list.
					
						2. He/she can compare effective drug groups for a selected indication in terms of “efficacy”, “safety”, “suitability” and “cost”.
					
						3. He/she can select a K-drug step by step for a given indication.
					
						4. He/she can compare effective drug molecules used in the selected indication in terms of “efficacy”, “safety”, “suitability” and “cost”.
					
						5. He/she can prepare a K-Treatment List created for a given indication.
					
						6. He/she can apply the K-Treatment list he/she created to the patient.
					
						7. He/she can determine the treatment goals by defining the patient’s problem.
					
						8. He/she can evaluate the suitability of the P-drug.
					
						9. He/she can start the treatment by writing a complete and correct prescription.
					
						10. He/she can establish a good patient-doctor relationship.
					
						11. Ability to provide the patient with necessary information and warnings about drug treatment
					
						12. Ability to monitor the drug treatment given and decide on the effectiveness of the treatment.
					
						13. Knows how and when to decide whether to continue, change, or stop the treatment.
					
						14. Knows how to review all treatment steps when the expected results are not obtained with the treatment.
					
				
	
	
	
 
				
	Week 1:
DAY 1
09:30 – 10:20 Introduction to Clinical Pharmacology
10:30 – 10:45 Preliminary Exam
10:45 – 11:00 Determining Groups
11:00 – 12:20 Definition of hypertension (Discussion)
Treatment options in hypertension (Discussion)
Determining Treatment Targets in Hypertension (Discussion)
12:20 – 13:30 Lunch Break
13:30 – 17:20 Creating the P-Drug Group List, Creating Tables and Discussion
DAY 2
09:30 – 10:20 Creation of P-Drug Group List, Creation of Tables and Discussion
10:30 – 12:20 Creation of P-Drug List,
Literature Evaluation and Preparation
12:20 – 13:30 Lunch Break
13:30 – 17:20 Creation of P-Drug List, Creation of Tables and Discussion
DAY 3
09:30 – 10:20 Creation of K-Treatment List, Literature Review and Preparation
10:30 – 12:20 Creation of K-Treatment List, Literature Review and Preparation
12:20 – 13:30 Lunch Break
13:30 – 14:20 Personal Medication List in Hypertension Emergency (Discussion), P-Drug List in Hypertension Treatment in Pregnancy (Discussion)
14:30 – 17:20 Creation of K-Treatment List, Creation of Tables and Discussion
DAY 4
09:30 – 12:20 Case Evaluation and Prescription
12:20 – 13:30 Lunch Break
13:30 – 17:20 Case Evaluation and Prescription
DAY 5
09:30 – 12:20 Case Evaluation and Prescription
12:20 – 13:30 Lunch Break
13:30 – 15:20 Case Evaluation and Prescription
15:30 – 17:20 Exam and Feedback
	
	
	
 
				
				
					
					
						
							
								
									| Tentative Assesment Methods | 
								
								
									| Activities | 
									Number | 
									Weight (%) | 
								
							
							
								
									
										| Course Attendance/Participation | 
										- | 
										- | 
									
								
									
										| Laboratory | 
										- | 
										- | 
									
								
									
										| Application | 
										- | 
										- | 
									
								
									
										| Homework | 
										- | 
										- | 
									
								
									
										| Project | 
										- | 
										- | 
									
								
									
										| Presentation | 
										- | 
										- | 
									
								
									
										| Field Work | 
										- | 
										- | 
									
								
									
										| Internship | 
										- | 
										- | 
									
								
									
										| Course Boards | 
										1 | 
										100% | 
									
								
									
										| Quiz | 
										- | 
										- | 
									
								
									
										| Midterm Exam | 
										- | 
										- | 
									
								
									
										| Final Exam | 
										- | 
										- | 
									
								
							
							
								
									 | 
									Total | 
									100% | 
								
							
						
						
						
							
								
									| Tentative ECTS-Workload Table | 
								
								
									| Activities | 
									Number/Weeks | 
									Duration (Hours) | 
									Workload | 
								
							
							
								
									
										| Course Hours (first 6 weeks) | 
										- | 
										- | 
										- | 
									
								
									
										| Course Hours (last 6 weeks) | 
										- | 
										- | 
										- | 
									
								
									
										| Laboratory | 
										- | 
										- | 
										- | 
									
								
									
										| Application | 
										- | 
										- | 
										- | 
									
								
									
										| Homework | 
										- | 
										- | 
										- | 
									
								
									
										| Project | 
										- | 
										- | 
										- | 
									
								
									
										| Presentation | 
										- | 
										- | 
										- | 
									
								
									
										| Field Work | 
										- | 
										- | 
										- | 
									
								
									
										| Internship | 
										- | 
										- | 
										- | 
									
								
									
										| Course Boards | 
										1 | 
										2 | 
										2 | 
									
								
									
										| Preparation for Quiz | 
										- | 
										- | 
										- | 
									
								
									
										| Preparation for Midterm Exam | 
										- | 
										- | 
										- | 
									
								
									
										| Final Exam | 
										- | 
										- | 
										- | 
									
								
									
										| Preparation for Final Exam | 
										- | 
										- | 
										- | 
									
								
									
										| Study Hours Out of Class (preliminary work, reinforcement, etc.) | 
										1 | 
										16 | 
										16 | 
									
								
							
							
								
									| Total Workload |  |  | 
									18 | 
								
								
									| Total Workload / 30 |  |  | 
									18 / 30 | 
								
								
									 |  |  | 
									0.600000 | 
								
								
									| ECTS Credits of the Course |  |  | 
									1 | 
								
							
						
					
				
			
				
					
						
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								Program Outcome
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							Course Outcome
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											 | 
										
									
								
									
									
									
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
							
						
							
								| 7 | 
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
											
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
											
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
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											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
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											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
							
						
							
								| 8 | 
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
											
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
							
						
							
								| 9 | 
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
											
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
											
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
							
						
							
								| 10 | 
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
											
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
							
						
							
								| 11 | 
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
											
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
							
						
							
								| 12 | 
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
											
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
							
						
							
								| 13 | 
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
											 | 
										
									
								
									
									
									
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
											
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
											
												
											 | 
										
										
										
									
								
									
									
									
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
										
										
										
										
									
									
									
										
										
										
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